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Danes je To dec 10, 2019 11:21

Keto/Low carb študije

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Šefe

Vnosov: 63904

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jul 19, 2019 20:43

Re: Keto/Low carb študije

Limfa, limfne žleze, limfedem in keto / LCHF

Eno od novejših odkritij je razkrilo, da je za regulacijo in rast limfnih žil esencialnega pomena acetil koencim A, ena od spojin, ki nastaja med presnovo. Preprosto povedano, acetil koencim A lahko sproži rast limfnih žil in izboljša njihovo delovanje tudi v bolezenskih razmerah, kot je na primer limfedem. Ker acetil koencim A lahko nastaja iz ketonov
, se je znanstvenikom porodila ideja, da bi nemara dodajanje ketonov povečalo razpoložljivo količino acetil koencima A in ugodno vplivalo na limfatični sistem.

To zanimivo idejo so sprva preskusili na človeških celicah v epruveti, potem pa še na živih miškah, ki so jim predpisali ketogeno dieto – in pri obeh se je izkazalo, da deluje.




https://www.lchflove.si/

2019/07/15/

limfa-limfne-zleze-limfedem

-in-keto-lchf/






Slika
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Grom

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Šefe

Vnosov: 63904

Pridružen: Če sep 23, 2004 18:35

Odgovor To jul 30, 2019 09:41

Re: Keto/Low carb študije

12 tednov ketogene diete je ne samo stabilziralo diabetes tipa 2, temveč je stanje reverzibiralo. Glikiran hemoglobin se je po 26 letih po diagnozi diabetesa vrnil v normalne vrednosti! Da ne govorimo o pozitivnem pogledu na življenje in odpravi depresije!

In potem še vedno vidim članek, da to ni prava prehrana za diabetike :)

Ketogenic diets potentially reverse Type II diabetes and ameliorate clinical depression: A case study.
Cox N1, Gibas S1, Salisbury M1, Gomer J2, Gibas K3.
Author information
Abstract

Efficacious adherence to treatment protocol predicts metabolic control among Type 2 diabetics (T2DM) [1-4]; however, few healthcare systems employ individualized strategies to mediate the comorbidity of T2DM with other chronic disease states. A clinically prescribed ketogenic diet, patient-centered nutritional education and high intensity interval training (HIIT), girded by solution-focused psychotherapy, modulate significant improvements in the clinical biomarkers associated with concurring T2DM and clinical depression [5-15]. Relevant metabolic change was noted in the following measures: HOMA-IR, triglyceride/HDL ratio, HgA1c, fasting insulin, fasting glucose, fasting triglycerides, LDL, VLDL, HDL, total cholesterol and C-reactive protein. The Patient Health Questionnaire 9 (PHQ-9) along with clinical interview and the mental status exam showed notable change in the patient's depressive symptoms; likewise, her self-efficacy score normalized, as measured by the General Self-Efficacy Questionnaire (GSE) and the Metabolic Syndrome Compliance Questionnaire (MSC). The case study highlights a 65-year old female who presented with a 26-year history of dually-diagnosed Type 2 diabetes (T2DM) and major depressive disorder (MDD). The patient was prescribed a ketogenic diet (KD), clinically formulated from her resting metabolic rate, body fat percentage and lean body mass, together with weekly nutrition education, high intensity interval training (matched to her cardiovascular conditioning), and eight 45-minute solution-focused psychotherapy sessions. Intervention goals included improved insulin sensitivity evaluated by the HOMA-IR, sustained glycemic control measured via HgA1c, reduced cardiovascular risk via the triglyceride/HDL ratio, and improved depressive symptoms with increased self-efficacy monitored by the PHQ-9 and GSE/MSC. The results of the 12-week intervention were statistically significant. The patient's HgA1c dropped out of diabetic range (8.0%) and normalized at 5.4%. Her average daily glucose measurements declined from 216 mg/dL to 96 mg/dL; the HOMA-IR and triglyceride/HDL ratios improved by 75%. Her marker for clinical depression and measurement of self-efficacy normalized. The 12-week individualized treatment intervention served to functionally reverse 26 years of T2DM, ameliorate two and half decades of chronic depressive disorder and empower/equip the patient with a new experience of hope and success.
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Grom

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Šefe

Vnosov: 63904

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe avg 02, 2019 08:12

Re: Keto/Low carb študije

Več raziskav kaže na pozitiven vpliv ketogene diete pri zmanjševanju pojava kroničnih glavobolov. To seveda vidimo tudi v praksi. Toda, kot kažejo moje izkušnje za optimum ni pomembna le LCHF prehrana temveč stanje visoke ketoze. Torej stroga ketogena dieta. Podobno v raziskavi:

Nutrients. 2019 Jul 28;11(8). pii: E1742. doi: 10.3390/nu11081742.
A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?


Here we aimed at determining the therapeutic effect of a very low-calorie diet in overweight episodic migraine patients during a weight-loss intervention in which subjects alternated randomly between a very low-calorie ketogenic diet (VLCKD) and a very low-calorie non-ketogenic diet (VLCnKD) each for one month. In a nutritional program, 35 overweight obese migraine sufferers were allocated blindly to 1-month successive VLCKD or VLCnKD in random order (VLCKD-VLCnKD or VLCnKD-VLCD). The primary outcome measure was the reduction of migraine days each month compared to a 1-month pre-diet baseline. Secondary outcome measures were 50% responder rate for migraine days, reduction of monthly migraine attacks, abortive drug intake and body mass index (BMI) change. Only data from the intention-to-treat cohort (n = 35) will be presented. Patients who dropped out (n = 6) were considered as treatment failures. Regarding the primary outcome, during the VLCKD patients experienced -3.73 (95% CI: -5.31, -2.15) migraine days respect to VLCnKD (p < 0.0001). The 50% responder rate for migraine days was 74.28% (26/35 patients) during the VLCKD period, but only 8.57% (3/35 patients) during VLCnKD. Migraine attacks decreased by -3.02 (95% CI: -4.15, -1.88) during VLCKD respect to VLCnKD (p < 0.00001). There were no differences in the change of acute anti-migraine drug consumption (p = 0.112) and BMI (p = 0.354) between the 2 diets. A VLCKD has a preventive effect in overweight episodic migraine patients that appears within 1 month, suggesting that ketogenesis may be a useful therapeutic strategy for migraines.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Sr sep 18, 2019 14:45

Re: Keto/Low carb študije

Ketogenic Diet and Skeletal Muscle Hypertrophy: a Frenemy Relationship?
Antonio Paoli


Abstract

Ketogenic diet (KD) is a nutritional regimen characterized by a high-fat and an adequate protein content and a very low carbohydrate level (less than 20 g per day or 5% of total daily energy intake). The insufficient level of carbohydrates forces the body to primarily use fat instead of sugar as a fuel source. Due to its characteristic, KD has often been used to treat metabolic disorders, obesity, cardiovascular disease, and type 2 diabetes. Skeletal muscle constitutes 40% of total body mass and is one of the major sites of glucose disposal. KD is a well-defined approach to induce weight loss, with its role in muscle adaptation and muscle hypertrophy less understood. Considering this lack of knowledge, the aim of this review was to examine the scientific evidence about the effects of KD on muscle hypertrophy. We first described the mechanisms of muscle hypertrophy per se, and secondly, we discussed the characteristics and the metabolic function of KD. Ultimately, we provided the potential mechanism that could explain the influence of KD on skeletal muscle hypertrophy.

Conclusions

Nutrients, growth factors, hormones, and muscle activity generate cellular signals that have the capacity to maintain and/or grow muscle mass. The regulation of skeletal muscle mass, in fact, reflects changes in protein synthesis and protein degradation, and several stimuli lead to protein synthesis and subsequent muscle hypertrophy. Indeed, nutrition is a key factor for muscle mass balance and macronutrients’ distribution, and the quantity may influence muscle growth and muscle response to training. The question that should be addressed is whether a diet in which one of the macronutrients is restricted, i.e. carbohydrates in KD, may affect skeletal muscle hypertrophy.

KD theoretically may affect skeletal muscle mass control pathways in several ways (Figure 2), but data provided by scientific literature suggest a negligible or no effect of KD on muscle mass with concomitant resistance training. KD may instead exert a protective effect against muscle mass loss during aging or during low calorie diets. The total effect seems to consist in the maintenance of muscle mass rather than a net hypertrophic effect.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Ne nov 03, 2019 10:31

Re: Keto/Low carb študije

Če raziskave ugotavljajo, da je super za ameriško vojsko bo tudi za nas.. :)


Extended Ketogenic Diet and Physical Training Intervention in Military Personnel
Richard A LaFountain, Vincent J Miller, Emily C

Military Medicine, usz046, https://doi.org/10.1093/milmed/usz046

Abstract
Introduction

Ketogenic diets (KDs) that elevate ketones into a range referred to as nutritional ketosis represent a possible nutrition approach to address the emerging physical readiness and obesity challenge in the military. An emerging body of evidence demonstrates broad-spectrum health benefits attributed to being in nutritional ketosis, but no studies have specifically explored the use of a KD in a military population using daily ketone monitoring to personalize the diet prescription.

Materials and Methods
To evaluate the feasibility, metabolic, and performance responses of an extended duration KD, healthy adults (n = 29) from various military branches participated in a supervised 12-wk exercise training program. Fifteen participants self-selected to an ad libitum KD guided by daily measures of capillary blood ketones and 14 continued their normal mixed diet (MD). A battery of tests were performed before and after the intervention to assess changes in body mass, body composition, visceral fat, liver fat, insulin sensitivity, resting energy metabolism, and physical performance.
Results

All KD subjects were in nutritional ketosis during the intervention as assessed by daily capillary beta-hydroxybutyrate (βHB) (mean βHB 1.2 mM reported 97% of all days) and showed higher rates of fat oxidation indicative of keto-adaptation. Despite no instruction regarding caloric intake, the KD group lost 7.7 kg body mass (range −3.5 to −13.6 kg), 5.1% whole-body percent fat (range −0.5 to −9.6%), 43.7% visceral fat (range 3.0 to −66.3%) (all p < 0.001), and had a 48% improvement in insulin sensitivity; there were no changes in the MD group. Adaptations in aerobic capacity, maximal strength, power, and military-specific obstacle course were similar between groups (p > 0.05).

Conclusions
US military personnel demonstrated high adherence to a KD and showed remarkable weight loss and improvements in body composition, including loss of visceral fat, without compromising physical performance adaptations to exercise training. Implementation of a KD represents a credible strategy to enhance overall health and readiness of military service members who could benefit from weight loss and improved body composition.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor To dec 03, 2019 14:06

Re: Keto/Low carb študije

Nekaj raziskav potrjuje uspešnost ketogene diete, kot terapije za demenco in Alzheimerjevo bolezen. Predvsem pa študije primerov in uspešna praksa. Potrebne so večje raziskave. Vendar je tu kot vemo velik problem sredstev. Največji finančni podporniki raziskav, torej farmacija in prehranska industrija opdadejo.Enostavno v pozitivnih učinkih KD ne vidijo koristi oziroma prej škodo. Podobno ugotavlja ta nov pregleden znanstven članek.

To treat or not to treat Alzheimer’s disease by the ketogenic diet? That is the question

Marzena Ulamek-Koziol1, Ryszard Pluta2 ORC ID

1 Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences; First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland

Conclusion and future perspective: To date, the results of using the ketogenic diet as a drug obtained in the treatment of neurodegenerative diseases seem to be particularly interesting in order to restore cognitive functions, although their number is limited. The few human studies available to date are based on a pre/post-design, but without a reference control group and no authentic randomization. The results showed causal evidence and underlined the need to increase the number of studies to demonstrate that the ketogenic diet induces cognitive improvement in neurodegenerative diseases. In recent years, the reputation of the ketogenic diet in terms of its therapeutic effects has been growing. In molecular research and partially polemic publications, the ketone diet gives misleading results because this diet has no single target point (Rusek et al., 2019). The authors of these discrepancies obtained their information from the data obtained in high-throughput screening. However, high-throughput screening is susceptible to technical artifacts and is therefore a deceptive tool because potential substances for drug can be omitted. In addition, the fact that the ketogenic diet, like many other natural substances, has more than one drug target, indicates its versatile use and low risk of inducing resistance to treatment. Although justified doubts exist and are crucial as to the reliability of therapeutic results, it makes no sense to disparage everything that has so far been published about the therapeutic effects of the ketogenic diet in the treatment of malignant gliomas, epilepsy or neurodegenerative diseases (Rusek et al., 2019). Instead, we should take the challenge of distinguishing between scientifically substantiated and false therapeutic results; otherwise, we will lose a promising substances for complementary and alternative treatment strategies. Rejecting some of the effects of ketogenic diet treatment would simply be ignorance. Opponents of the ketogenic diet criticize the fact that it has never been demonstrated to be definitely effective in a randomized placebo-controlled clinical trial for any indication (Rusek et al., 2019). Critics should consider the fact that it is almost impossible to get financial support for conducting a clinical trial with a substance that cannot be patented and is therefore not economically interesting. Another point to consider is the study design, the ketogenic diet cannot be tested in randomized placebo-controlled studies because currently clinical trials are conducted as test substance against standard therapy, otherwise the study will not be approved by the ethics committee. Therefore, the question is against which drug currently used to treat AD should we test the ketogenic diet? There is no doubt that due to comprehensive data from preclinical studies, along with the first results of individual patients or small cohorts (Rusek et al., 2019), the next task must be to test ketogenic diet in well-designed clinical trials. However, the biggest challenge will be finding sponsors for clinical trials on ketogenic diet as this promising diet cannot be exploited economically. Further double-blind investigations are needed to clarify the effectiveness of taking the ketogenic diet. In summary, future studies should focus on the correct identification of patients (in terms of age, type and duration of AD, comorbidities, and Apo E 4 allele+/–) and they are necessary to answer the question in the title.[10]
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Sr dec 04, 2019 18:32

Re: Keto/Low carb študije

Eden izmed največjih tračev v zvezi s to prehrano je da škodi jetrom. Prav tako, da ni primerna za zamaščena jetra in povišane trigliceride. No to je velika zmota. Pogosto jo širijo tudi zdravniki s svojim neznajem o vplivu prehrane na telo. Raziskave in tudi praksa kažejo ravno obratno. Pri zamaščenih organih in povišanih trigliceridih pa bi morala za moje pojme biti ta prehrana prvi izbor. Ko telesu omogočimo, da bo za energijo optimalno kurilo maščobe prvo padejo trigliceridi in se odmastijo organi. In to se zgodi v zelo kratkem času.
Najnovejša raziskava se ukvarjam z mehanizmi pozitivnih vpliov te prehrane na delovanje jeter.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans


Highlights

A low-carbohydrate diet (LCD) improves liver fat metabolism in NAFLD patients
The LCD promotes rapid shifts in the gut microbiota composition of NAFLD patients
The LCD-induced microbial changes are associated with increased circulating folate
The LCD increases folate-dependent one-carbon metabolism gene expression in liver

Summary
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum β-hydroxybutyrate concentrations, reflecting increased mitochondrial β-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations. Liver transcriptomic analysis on biopsy samples from a second cohort revealed downregulation of the fatty acid synthesis pathway and upregulation of folate-mediated one-carbon metabolism and fatty acid oxidation pathways. Our results highlight the potential of exploring diet-microbiota interactions for treating NAFLD.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe dec 06, 2019 09:21

Re: Keto/Low carb študije

Še ena zanimiva najnovejša raziskava, ki kaže na terapevtski potencial ketogene diete in višje ketoze pri policistični bolezni ledvic.


Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

https://doi.org/10.1016/j.cmet.2019.09.012

Highlights

•Ketosis prevents or reverses PKD in animal models
•Dietary changes that induce ketosis prevent PKD
•Oral β-hydroxybutyrate supplementation alone inhibits PKD progression
•Cystic cells are metabolically inflexible, which can be exploited for therapy

Summary

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD) progression in mouse models, but whether the effect was due to solely reduced calories or some other aspect of the diet has been unclear. We now show that the benefit is due to the induction of ketosis. Time-restricted feeding, without caloric reduction, strongly inhibits mTOR signaling, proliferation, and fibrosis in the affected kidneys in a PKD rat model. A ketogenic diet had a similar effect and led to regression of renal cystic burden. Acute fasting in rat, mouse, and feline models of PKD results in rapid reduction of cyst volume, while oral administration of the ketone β-hydroxybutyrate (BHB) in rats strongly inhibits PKD progression. These results suggest that cystic cells in PKD are metabolically inflexible, which could be exploited by dietary interventions or supplementation with BHB, representing a new therapeutic avenue to treat PKD.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Ne dec 08, 2019 13:37

Re: Keto/Low carb študije

Že skoraj 100 let se ketogena dieta uspešno uporablja pri določenih oblikah epilepsije. V zadnjih desetetletjih predvsem tam, kjer zdravila ne pomagajo. In to z dokaj veliko uspešnostjo. Pred zdravili pa je bil to seveda prvi pristop. Po 100 letih je eden največjih raziskovalcev ketogene diete v povezavi z epilepsijo in avtor knjig Eric Kossoff pripravil nov znanstven članek.


Ketogenic Dietary Therapy Controversies for Its Second Century
Eric Kossoff MD*, Mackenzie Cervenka, MD
First Published December 2, 2019 Review Article
https://doi.org/10.1177/1535759719890337


Abstract

As the ketogenic diet approaches 100 years of continuous use, we reflect on its successes and consider new avenues of research for the next century. One controversial question is regarding whether ketogenic dietary therapies could be successful first-line treatments for epilepsy. Second, is it possible to mimic the mechanisms of action of ketogenic dietary therapy with a drug (eg, a tablet formulation)? A third controversy worthy of future study involves its expanded usage in adults with refractory epilepsy and its role in treating women of childbearing age. Finally, as flexible, alternative diets have recently become widely available, is it feasible and safe to have families and patients start ketogenic dietary therapy successfully on their own with limited medical supervision?

Conclusions

Ketogenic dietary therapies for epilepsy, proposed as a treatment 100 years ago, have reemerged from dormancy in the past several decades and gained worldwide acceptance. Studies have resolved questions regarding efficacy, patient populations with specific seizure disorder and epilepsy syndrome types that would benefit most, overall adverse effect profile and management, and even incorporated flexibility in initiation and maintenance. Many important questions remain to be studied, and this review highlights just four of these controversial issues. Hopefully, further investigation will address these research topics and stimulate further hypotheses to be explored in the next century of use and beyond.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Po dec 09, 2019 18:45

Re: Keto/Low carb študije

Še ena letos objavljena raziskava, ki potrjuje učinkovitost LCHF prehrane pri zdravljenju diabetesa tipa 2. Diabetes je bil v tej, kot tudi nekaterih drugih raziskavah in pogosto v praksi ustavljen. Kazalci zdravja so se vračali na prave vrednosti. Potreba po zdravilih se je zmanjšala oziroma ta več niso bila potrebna. Osebe so bile na tej prehrani pravzaprav zdrave, kar je pomembno tudi iz stališča preprečevanja posledic diabetesa na dolgi rok. Seveda so osebe poročale o sitosti in povečani energiji ter zmanjšani želji po prenajedanju s slabo prehrano.
LCHF je prava pot!


Diet, Diabetes Status, and Personal Experiences of Individuals with Type 2 diabetes Who Self-Selected and Followed a Low Carbohydrate High Fat diet

Published 5 December 2019 Volume 2019:12 Pages 2567—2582

Christopher C Webster, Tamzyn E Murphy, Kate M Larmuth, Timothy D Noakes, James A Smith


Background: Low carbohydrate high fat (LCHF) diets are increasing in popularity amongst patients with type 2 diabetes (T2D), however it is unclear what constitutes a sustainable LCHF diet in a real-world setting.
Methods: This descriptive multi-method study characterized the diets, T2D status, and personal experiences of individuals with T2D who claimed to have followed an LCHF diet for at least 6 months. Participants completed a medications history, mixed-method dietary assessment, provided a blood sample, and were interviewed in-depth about their experiences with the diet (First-Assessment). Past medical records were obtained corresponding to T2D diagnosis and prior to starting their LCHF diets. Additionally, participants were followed up 15 months later to assess T2D remission (Follow-Up).

Results: Twenty-eight participants completed First-Assessment and 24 completed Follow-Up. Habitual carbohydrate intake was 20 to 50 g/d for 10 participants and 50 to 115 g/d for 17 participants. Commonly reported foods were full-fat dairy, non-starchy vegetables, coconut oil, eggs, nuts, olives and avocados, olive oil, and red meat and poultry with fat. Median (interquartile range) for HbA1c was 7.5 (6.5–9.5) % prior to starting their diets, 5.8 (5.4–6.2) % at First-Assessment and 5.9 (5.3–6.6) % at Follow-Up. Reported body weight and glucose-lowering medication requirements were considerably lower at both assessments than when starting the diet. At Follow-Up, 24 participants had been following their LCHF diets for 35 (26–53) months, the majority of which were in full or partial T2D remission. Participants perceived reduced hunger and cravings as one of the most important aspects of their diets. Of concern, many participants felt unsupported by their doctors.
Conclusion: This study described the foods and characteristics of an LCHF “lifestyle” that was sustainable and effective for certain T2D patients in a real-world setting.
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