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Danes je Po okt 14, 2019 16:43

Ecdysteroids as non-conventional anabolic agent

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jul 19, 2019 20:45

Ecdysteroids as non-conventional anabolic agent

Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans

Abstract

Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 “other anabolic agents”.
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Grom

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jul 19, 2019 20:47

Re: Ecdysteroids as non-conventional anabolic agent

Spinach Extract Improves Athletic Performance, Study Shows
Freie Universität Berlin Contributes to Research Project Backed by the World Anti-Doping Agency

№ 193/2019 from Jun 25, 2019

According to a study conducted by a group of international researchers, including experts from Freie Universität Berlin, a chemical extract from spinach plants can be used to boost the performance of competitive athletes. The World Anti-Doping Agency (WADA) commissioned researchers to study the effects of ecdysterone, a kind of phytosteroid, on strength training. Their findings indicate that the substance greatly affects muscle cells. Among the researchers who suggested to consider adding ecdysterone to the list of prohibited substances was Maria Parr, a professor of Pharmaceutical Chemistry at Freie Universität. Professor Parr specializes in pharmaceutical analytics and metabolism. Phytosteroids belong to the chemical class of substances known as sterols and can be found naturally in plants. They are chemical derivatives of cholesterol. In addition to Maria Parr from Freie Universität, other contributing researchers included Prof. Patrick Diel from the German Sport University Cologne, Prof. Francesco Botrè from the anti-doping laboratory in Rome, and Dr. Catrin Goebel from the anti-doping laboratory in Sydney.

In the double-blind study, one group of athletes received a controlled amount of the spinach extract, while another received a placebo, without either knowing which they were taking. After the ten-week study period, the athletes who actually took ecdysterone showed a significantly higher increase in maximum muscle strength.

Ecdysterone is the main component in spinach extracts. The research team was able to show that the substance affects estrogen receptor beta. Many dietary supplements on the market contain the spinach chemical. Maria Parr noted that ecdysterone had already been dubbed “the Russian secret” for enhancing athletic performance several years ago. Earlier in vitro and animal experiments showed that it had a very strong effect on muscle cells, even stronger than anabolic androgenic steroids, such as metandienone, which are prohibited in sports. Professor Parr further explained that the low dose of two pills per day, which they used for some of the participants in the experiment, would amount to anywhere between 250 grams and four kilograms of spinach per day, depending on the variety and harvesting of the plant. A person would have to eat that amount every day over the course of ten weeks in order to consume the same amount as one of the “low-dose athletes” in the study. In order to consume the same level as those administered high doses, a person would have to eat between one to 16 kilograms of spinach, she explained.

In order to enable other WADA accredited laboratories to detect an administration of ecdysterone in doping control samples, Professor Parr and her team developed LC-MS/MS and GC-MS methods. These methods allow doping control laboratories to integrate ecdysterone and its main metabolites into their testing procedures.
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