Odgovor Po sep 07, 2015 05:26

Is supplemental GABA the best option for sleep aid?

Is supplemental GABA the best option for sleep aid?

Gamma-Aminobutyric Acid, (GABA) is the primary inhibitory neurotransmitter in the body. As an inhibitory neurotransmitter, when GABA attaches to GABA receptors in the brain, it causes a reduction in neuron transduction. Increasing GABA levels in the brain could theoretically have a calming, sedative effect. In order to understand how GABA works, consider the action of caffeine. Caffeine in part, inhibits the release of GABA, which results in feelings of wakefulness and attentiveness.

However, due to tight regulation of GABA concentrations in the brain, orally consumed GABA supplementation does not seem to cross the blood brain barrier efficiently. Further, the brain excretes excess GABA in order to keep levels constant. As a result, oral GABA supplementation has not been proven to be an effective supplement.

A potential sleep aid alternative is L-Theanine or 5-HTP. A study by Lyon et al., in 2011 presents data indicating that ingestion of 400 mg of the amino acid L-Theanine may improve sleep percentage and sleep efficiency. If you are interested in L-Theanine, it is suggested to begin with 100 mg and increase dosage as needed.
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