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Danes je So nov 16, 2019 23:09

And what happens when you Fast for 10 Days

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe mar 11, 2016 22:50

And what happens when you Fast for 10 Days

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According to the NIH (2016), the protein encoded by FGF21 is part of the FGF (fibroblast growth factor) family. This family of proteins deals with tissue repair, cell growth, tumor growth, morphogenesis, and other processes. [3]

Data from mouse models (FGF21 transgenic mice) attribute various functions to FGF21:

– induction of ketogenesis and gluconeogenesis [4] [5] [6] [7]
– growth hormone resistance (preventing energy expenditure on growth) [8]
– disruption of the HPO axis (minimizing energy expenditure on reproduction) [9]

Researchers explain [1]:

FGF21 transgenic mice are also resistant to a high-fat/high-carbohydrate diet; despite eating more food than do their WT littermates, they gain less weight, an effect that appears to be at least partially mediated by induction of thermogenesis. Why a hormone that is upregulated during starvation would enhance weight loss and induce thermogenesis is unknown.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe mar 11, 2016 22:54

Re: And what happens when you Fast for 10 Days

Unlike mice, which show an increase in circulating FGF21 after only 6 hours, human subjects did not have a notable surge in FGF21 until 7 to 10 days of fasting.



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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe mar 11, 2016 22:59

Re: And what happens when you Fast for 10 Days

For example, it is possible that the administration of FGF21 to humans in the fed state may promote increased energy expenditure and uncoupled thermogenesis. If FGF21 or related mimetics continue to advance through the drug development pipeline, it may be that their efficacy and any potential off-target effects will be highly dependent on coexistent nutritional status.
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