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Human Growth Hormone (HGH) declines with age in every animal species. In humans, after the age of 20-30 HGH levels decline 14-15% every 10 years; by the age of 60 HGH is usually less than half what it was at 25. At 20 our pituitary produces about 500mg a day, at 40 only 200 mg/day, and at 60 it’s down to 25mg/day. IGF-1 (insulin like growth factor) mirrors that same decline. While HGH is released in tiny spurts (more at night) it is only viable in the blood for a few minutes. It stimulates IGF-1 to be released by the liver and has a much longer half-life. Therefore, it is easier to measure the IGF-1 levels in the blood as an indicator of how much HGH is released, than it is to try to catch the tiny amounts of HGH when they are rereleased sporadically.

Daniel Rudman, M.D., the main pioneer researcher of HGH in 1986, determined IGF-1 levels under 350 to be indicative of deficiency. He found that from age 20-40 years, 95% of healthy men have IGF-1 levels greater than 350. However, after 60 years old 30% of healthy men drop below 350 and after 65 years old well over 50% of the population have very low levels of HGH.

However, when properly stimulated, the pituitary gland has the ability to release as much HGH as it did during it’s 20’s; it’s ability to produce hormone does not decline. On the other hand, the hypothalamus which stimulates HGH levels to begin with, becomes less responsive to the body's requests for GH as we age. In fact, it also secretes Somatostatin which suppresses HGH and other hormones causing aging.

From his breakthrough pioneer work in 1986 using recombinant injectable growth hormone on a group of seniors Dr. Rudman and his team discovered the following body improvements:

memory improvement
fewer wrinkles
thicker skin with more collagen
less cellulite
better vision
increased energy
better exercise performance and an 8.8% increased muscle mass
14.4% reduction in body fat
a stronger heart with improved cardiac output
stronger bones
decreased osteoporosis
improved wound healing
organ revitalization
shorter healing time for wounds

Just as our face wrinkles and body parts droop and loosen, so do our organs decrease in size and output with age. However, bodybuilders who inject high levels of HGH have been known to develop an enlarged abdomen due to the fact that the HGH has actually increased the size an output of their organs.

In updating the original Rudman study reported in JAMA 9n 1968, Dr. Cass Terry M.D., PhD, in 1999 reported on a study completed by Blackman and Harman which looked at 125 patients (71 males and 52 females age 65-88) receiving HGH injections over a six-month period of time. The results proved the ability to reverse aging by raising hormones to the levels of healthy young adults. In the study one group was given just growth hormone via injection, while the other males were injected with a combination of HGH and testosterone. The female group received a combination of HGH and estrogen. A third group was only given a placebo.

Impressive anti-aging results were astounding with improvement in the following:

attitude and emotional stability improved in 62% of patients
energy levels increased in 84% of patients
skin texture, thickness and elasticity improved in over 68% of patients
frequency and duration or sexual intercourse improved in nearly 75% of patients.

Practically all HGH studies since the original by Rudman demonstrate the above improvements.
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