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Danes je Pe dec 06, 2019 23:37

Če je keto za kaj top je za možgane

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Šefe

Vnosov: 63896

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe sep 02, 2016 11:13

Če je keto za kaj top je za možgane

Veliko pozitivnih raziskav. Nevrogeneza, pretok krvi v možgane, nevroprotektično delovanje, odlično gorivo, manj spanja itd... Eden od razlogov, da ostanem na keto večno in ne pomislim na drugo hrano..

Še ena nova raziskava:

Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

Miho Ota, Junko Matsuo, Ikki Ishida, Kotaro Hattori, Toshiya Teraishi, Hidekazu Tonouchi, Kinya Ashida, Takeshi Takahashi, Hiroshi Kunugi

Abstract
Rationale

Glucose is the principal energy substrate for the brain, although ketone bodies are an effective alternative. Evidence suggests that elevation of plasma ketone body levels through oral intake of medium chain triglycerides (MCTs) may improve cognitive function.
Objectives

We tried to examine the possible effects of a ketogenic meal serving on cognition in elderly non-demented subjects.
Methods

Subjects were 19 non-demented elderly adults over 60 years old (13 females; mean age: 66.1 ± 2.9 years) who underwent neurocognitive tests 90 and 180 min after oral intake of a ketogenic meal (Ketonformula®) containing 20 g of MCTs and an isocaloric placebo meal without MCTs on separate days.
Results

Elevation of plasma ketone concentration after intake of a single ketogenic meal containing 20 g of MCTs was confirmed (all p < 0.001). As for cognition, improvements were observed in the digit span test, Trail-Making Test B, and the global score (Z = −2.4, p = 0.017) following the ketogenic meal and the change in the executive functioning score was positively correlated with that of the plasma β-hydroxybutyrate level. The cognition-enhancing effect was observed predominantly for individuals who had a relatively low global score at baseline (Z = −2.8, p = 0.005), compared to individuals with a high global score (Z = −0.7, p = 0.51).
Conclusions

Plasma levels of ketone bodies were successfully increased after intake of the ketogenic meal. The ketogenic meal was suggested to have positive effects on working memory, visual attention, and task switching in non-demented elderly.
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Grom

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Šefe

Vnosov: 63896

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe sep 02, 2016 11:14

Re: Če je keto za kaj top je za možgane

Ena najpomembnejših stvari je pretok krvi v možgane. Tako deluje tudi veliko nootropicov zdravil za izboljšanje delovanja možganov


J Cereb Blood Flow Metab. 2006 Feb;26(2):170-80.
Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat.
Linde R1, Hasselbalch SG, Topp S, Paulson OB, Madsen PL.
Author information
Erratum in

J Cereb Blood Flow Metab. 2006 Mar;26(3):448.

Abstract

In the human setting, it has been shown that acute increase in the concentration of ketone bodies by infusion of beta-hydroxybutyrate increased the cerebral blood flow (CBF) without affecting the overall cerebral metabolic activity. The mechanism by which this effect of ketone bodies was mediated is not known. Alterations in several parameters may possibly explain the increase in CBF and the resetting of the relation between CBF and cerebral metabolism. To study this phenomenon further, we measured global CBF and global cerebral metabolism with the Kety-Schmidt technique in the wakeful rat before and during infusion of ketone bodies. During acute hyperketonemia (average concentration of beta-hydroxybutyrate: 6 mmol/L), global CBF increased 65% from 108 to 178 mL/100 g min and the cerebral metabolic rates for both oxygen and glucose remained constant. This resetting of the relation between CBF and cerebral metabolism could not be explained by alterations in blood pH or arterial CO2 tension. By measuring cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy, it could further be concluded that the brain pH was unchanged during acute hyperketonemia. These observations indicate that the mechanism responsible for the increase in CBF is rather a direct effect on the cerebral endothelium than via some metabolic interactions.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe sep 02, 2016 11:14

Re: Če je keto za kaj top je za možgane

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
Ai-Ling Lin,a,b,* Wei Zhang,c Xiaoli Gao,d,e and Lora Wattsc,f
Author information ► Copyright and License information ►
The publisher's final edited version of this article is available at Neurobiol Aging
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Abstract

Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging.
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Grom

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Šefe

Vnosov: 63896

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe sep 02, 2016 11:16

Re: Če je keto za kaj top je za možgane

Pravzaprav se pojavljajo hipoteza, da ima za razvoj človeka večji pomen povečan pretok krvi kot veliko povečanje velikosti možganov


Smarter brains are blood-thirsty brains
August 30, 2016
Smarter brains are blood-thirsty brains
Skull casts from human evolution. Left to right: Australopithecus afarensis, Homo habilis, Homo ergaster, Homo erectus and Homo neanderthalensis. Credit: Roger Seymour. Casts photographed in the South Australian Museum.

A University of Adelaide-led project has overturned the theory that the evolution of human intelligence was simply related to the size of the brain—but rather linked more closely to the supply of blood to the brain.

The international collaboration between Australia and South Africa showed that the human brain evolved to become not only larger, but more energetically costly and blood thirsty than previously believed.

The research team calculated how blood flowing to the brain of human ancestors changed over time, using the size of two holes at the base of the skull that allow arteries to pass to the brain. The findings, published in the Royal Society Open Science journal, allowed the researchers to track the increase in human intelligence across evolutionary time.

"Brain size has increased about 350% over human evolution, but we found that blood flow to the brain increased an amazing 600%," says project leader Professor Emeritus Roger Seymour, from the University of Adelaide. "We believe this is possibly related to the brain's need to satisfy increasingly energetic connections between nerve cells that allowed the evolution of complex thinking and learning.

"To allow our brain to be so intelligent, it must be constantly fed oxygen and nutrients from the blood.


Read more at: http://phys.org/news/2016-08-smarter-br ... y.html#jCp
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