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Danes je Sr okt 16, 2019 08:01

Keto/Low carb študije

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor To mar 19, 2019 14:26

Re: Keto/Low carb študije

Ker prehranska in farmacevtska industrija od keto diete nimata ravno koristi (prej škodo :)), prihaja večji del denarja za keto raziskave iz strani amerišk vojske. Večkrat sem na konferencah že poslušal o uporabi keto diete pri ameriških specialcih že nekaj desetletji nazaj, ki so na terenu dolgo brez hrane, spanja in v zelo težkih pogojih. Glede na visoko raven energije brez, ki težko zmanjka ter tudi brez potrebe po hranjenu, višjo raven koncetracije in manjšo potrebo po spancu je izbore te prehrane logičen.

Zanimiva je tudi nova raziskava, ki kaže na hitro izgubo maščobe, izbolšanje kazalnikov zdravja ob hkratnem ohranjanju telesnih sposobnostih na keto prehrani pri ameriških vojakih.

Mil Med. 2019 Mar 16.

Abstract

INTRODUCTION:

Ketogenic diets (KDs) that elevate ketones into a range referred to as nutritional ketosis represent a possible nutrition approach to address the emerging physical readiness and obesity challenge in the military. An emerging body of evidence demonstrates broad-spectrum health benefits attributed to being in nutritional ketosis, but no studies have specifically explored the use of a KD in a military population using daily ketone monitoring to personalize the diet prescription.

MATERIALS AND METHODS:

To evaluate the feasibility, metabolic, and performance responses of an extended duration KD, healthy adults (n = 29) from various military branches participated in a supervised 12-wk exercise training program. Fifteen participants self-selected to an ad libitum KD guided by daily measures of capillary blood ketones and 14 continued their normal mixed diet (MD). A battery of tests were performed before and after the intervention to assess changes in body mass, body composition, visceral fat, liver fat, insulin sensitivity, resting energy metabolism, and physical performance.

RESULTS:

All KD subjects were in nutritional ketosis during the intervention as assessed by daily capillary beta-hydroxybutyrate (βHB) (mean βHB 1.2 mM reported 97% of all days) and showed higher rates of fat oxidation indicative of keto-adaptation. Despite no instruction regarding caloric intake, the KD group lost 7.7 kg body mass (range -3.5 to -13.6 kg), 5.1% whole-body percent fat (range -0.5 to -9.6%), 43.7% visceral fat (range 3.0 to -66.3%) (all p < 0.001), and had a 48% improvement in insulin sensitivity; there were no changes in the MD group. Adaptations in aerobic capacity, maximal strength, power, and military-specific obstacle course were similar between groups (p > 0.05).

CONCLUSIONS:

US military personnel demonstrated high adherence to a KD and showed remarkable weight loss and improvements in body composition, including loss of visceral fat, without compromising physical performance adaptations to exercise training. Implementation of a KD represents a credible strategy to enhance overall health and readiness of military service members who could benefit from weight loss and improved body composition.
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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Ne mar 24, 2019 11:47

Re: Keto/Low carb študije

Ravno objavljena še ena izmed nekaj raziskav, ki kažejo na učinkovitost ketogene dieti pri rakavih bolnikih v smislu ohranjanja mišične mase oziroma celotne puste mase in zmannjšanja oslabitve organizma, ki je običajno posledica bolezni oziroma uporabe raznih terapij.
Le še eden izmed mehanizmov preko katerih ima KD lahko pozitiven vpliv pri bolnikih, ki so zboleli za rakom.
A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy:
An interim analysis of the KETOCOMP study

Highlights
•Consumption of a ketogenic diet (KD) during radio(chemo-)therapy is feasible.
•In rectal and breast cancer patients, the KD significantly reduced fat mass.
•Fat-free mass and skeletal muscle mass were preserved by the KD.
•In head and neck cancer patients a KD influenced body composition opposite to chemotherapy.
Abstract
Ketogenic diets (KDs) have gained interest as a complementary treatment for cancer patients. Here we present first results of our ongoing KETOCOMP study (NCT02516501) concerning body composition changes among rectal, breast and head & neck cancer (HNC) patients who consumed a KD during curative radiotherapy (RT).
Experimental procedure
Sixty-one patients eating a non-ketogenic diet were compared to 20 patients on a KD supplemented with 10 g essential amino acids on RT days. Body composition was measured prior to and weekly during RT using 8-electrode bioimpedance analysis. Longitudinal body composition data were analyzed using linear mixed effects models.
Results and conclusion
Patients on the KD exhibited nutritional ketosis, defined as serum β-hydroxybutyrate levels ≥0.5 mmol/l, in a median of 69.0% of blood measurements (range 0–100%) performed in our clinic. In rectal and breast cancer patients, KD was significantly associated with a loss of 0.5 and 0.4 kg fat mass per week (p = 0.00089 and 8.49 × 10−5, respectively), with no significant changes in fat free and skeletal muscle mass. In HNC patients, concurrent chemotherapy was the strongest predictor of body weight, fat free and skeletal muscle mass loss during RT, while consuming a KD was significantly associated with a gain in these measures. These preliminary results confirm prior reports indicating that KDs are safe to consume during standard-of-care therapy. They also provide an important first indication that KDs with ample amino acid intake could improve body composition during RT in curative cancer patients.
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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Sr mar 27, 2019 08:48

Re: Keto/Low carb študije

Poškodbe in slabo delovanje celičnih mitohondrijev so stanja povezana z vsemi bolezenskimi stanji sodobnega časa. Od nevroloških bolezni do raka. Zdravje in dobro delovanje mitohondrijev je pomembno za vse organe. Dobro delovanje energijskega sistema je pomembno za naše zdravje in ohrananje vitalnosti tudi ko se staramo. Vadba je eden izmed načinov, kako izboljšamo delovanje mitohondrijev ter povečamo njihovo število v telesu. Zato velja za nekaj zdravega.
Še bolj kot vadba pa genezo mitohondrijev in njihovo obnovo spodbuja ketogena dieta. Cel kup raziskav. In pred kratkim objavljena še ena, ki nakazuje to smer..

Mitochondrial quality control in aging and heart failure: influence of ketone bodies and mitofusin stabilizing peptides

Aim: Mitochondrial function declines with age, and progressive mitochondrial damage may impair cellular function and contribute to heart failure (HF) development. Proper removal of damaged mitochondria (mitophagy) is essential for cardiovascular health, and is affected by metabolic substrates and nutrient depriviation. HF has metabolic similarities to starvation where increased formation and consumption of ketone bodies (KBs) is observed. Here, we tested the hypothesis that KBs contribute to activation of mitophagy in aging and HF.

Methods: We assessed mitophagy by measuring mitochondrial Parkin accumulation and LC3-mediated autophagosome formation in cardiomyocytes from young (2.5 months), aged (2.5 years) and rabbits with HF (2.5 years) induced by aortic insufficiency and stenosis. Levels of reactive oxygen species (ROS) generation and redox balance were monitored using genetically encoded sensors ORP1-roGFP and GRX1-roGFP, targeted to mitochondrial or cytosolic compartments.

Results: Young rabbits exhibited limited mitochondrial Parkin accumulation with small (~1 µm2) puncta. Those small Parkin puncta increased 4-fold in aged rabbit hearts, accompanied by elevated LC3-mediated autophagosome formation. HF hearts exhibited fewer small puncta, but many very large Parkin-rich regions (4-5 µm2) with completely depolarized mitochondria. Parkin protein expresson was barely detectable in young, much higher in aged and maximal in HF hearts. Mitofusin 2 (MFN2) expression was reduced by almost 50% in HF, consistent with improper fusion-fission contributing to mitochondrial Parkin build-up. The ketone body β–hydroxybutyrate (β-OHB) enhanced mitophagic flux in young and aging myocytes, but not in HF where β-OHB further increased the number of cells with giant Parkin-rich fusions. This β-OHB effect on Parkin-rich areas was prevented by cell-permeant TAT-MP1Gly peptide (thought to promote MFN2-dependent fusion). Mitochondrial ROS was highest in HF and partially decreased by β-OHB. However, basal cytosolic ROS was highest in aged myocytes and lower in HF (but β-OHB partially restored ROS). We suggest that basal cytosolic ROS could serve as a signal to activate Parkin recruitment to the mitochondria.

Conclusion: We conclude that elevated ketone body levels are beneficial for mitochondrial repair in the aging heart. However impaired MFN2-mediated fusion-fission process in HF reduces this benefit, as well as Parkin degradation and mitophagic flux.
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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor To apr 09, 2019 07:23

Re: Keto/Low carb študije

Ketogenic diet in combination with voluntary exercise impacts markers of hepatic metabolism and oxidative stress in male and female rats

Abstract
Introduction

High-fat, very low carbohydrate, ketogenic diets (KD) have been shown to benefit hepatic lipid metabolism; however, the effects of KD on hepatic metabolism when combined with regular exercise is unknown. Here, we investigated the effects of KD vs. high fat, high carbohydrate Western diet (WD) on markers of hepatic lipid metabolism and oxidative stress in voluntarily exercised male and female rats.
Methods

Male and female Wistar rats (7 weeks of age) were given access to voluntary running wheels and randomized into three groups (n= 8–14) with standard chow (SC; 26.5%, 56.5%, 17%-PRO, CHO, FAT), WD (15.2%, 42.7%, 42% & 0.2% cholesterol by weight) or KD (9.2%, 0.3%, 90.5%) for 7 weeks. WD and KD groups were pair-fed to calorically match SC controls.
Results

KD and WD feeding (p≤0.05) decreased food intake (kcals/week) relative to SC fed in male but not in female rats, with KD fed males gaining less body weight vs. SC and WD males (p≤0.05). In addition, body fat percentage (BF%) was increased in WD and KD vs. SC in both males and females (p≤0.05), although female KD fed rats displayed a lower BF% relative to female WD. Female rats ran more than males (12.0±0.3 km/wk vs. 5.4±0.7 km/wk, p≤0.05). Liver triglycerides (TAGs) were higher in KD and WD fed animals vs. SC controls (p<0.001), but were attenuated in female KD vs. female WD rats (p<0.05). KD feeding dramatically suppressed hepatic protein markers of de novo lipogenesis [fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC)], and increased markers of mitochondrial biogenesis/content; PGC-1α, mitochondrial transcription factor A and citrate synthase activity in both males and females. KD feeding also increased the antioxidant enzyme glutathione peroxidase 1 (GPx1) vs. SC and WD in both males and females and lowered the antioxidant response factor nuclear factor E2-related factor 2 (NRF2) vs. SC only within males. Interestingly, females exhibited elevated hepatic protein markers of mitophagy light chain 3 (LC3 II/I ratio), autophagy-related protein (ATG 12:5) and cellular energy homeostasis (phospho- 5′ AMP-activated protein kinase (AMPK)/AMPK ratio) with decreased NRF2 protein content (p<0.05) compared with males. On the other hand, protein content of markers of mitochondrial biogenesis/content PGC-1α and oxidative phosphorylation-Complex IV were lower (p<0.05) in females vs. males.
Conclusion

When compared with a Western-style diet, KD feeding in combination with voluntary exercise in rats promoted improved body composition and hepatic oxidative stress, suppressed of markers of hepatic de novo lipogenesis, and increased markers of hepatic mitochondria content and function. These adaptations occurred in the presence of elevated hepatic TAGs. More thorough investigation of the molecular pathways activated by ketogenic diet feeding with exercise are warranted.

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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Po apr 15, 2019 12:58

Re: Keto/Low carb študije

Praksa in raziskave kažejo, da je ketogena dieta pogosto super terapija za ljudi s pogostimi glavoboli. Tudi veliko strank, ki so imele probleme mi po nekaj tednih te prehrane o tem porača.
Ravno pa je bila objavljena še ena raziskava na to temo.
Potential Protective Mechanisms of Ketone Bodies in Migraine
An increasing amount of evidence suggests that migraines are a response to a cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic diet (KD), a diet mimicking fasting that leads to the elevation of ketone bodies (KBs), is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraines. KBs are an alternative fuel source for the brain, and are thus likely able to circumvent some of the abnormalities in glucose metabolism and transport found in migraines. Recent research has shown that KBs-D-β-hydroxybutyrate in particular-are more than metabolites. As signalling molecules, they have the potential to positively influence other pathways commonly believed to be part of migraine pathophysiology, namely: mitochondrial functioning, oxidative stress, cerebral excitability, inflammation and the gut microbiome. This review will describe the mechanisms by which the presence of KBs, D-BHB in particular, could influence those migraine pathophysiological mechanisms. To this end, common abnormalities in migraines are summarised with a particular focus on clinical data, including phenotypic, biochemical, genetic and therapeutic studies. Experimental animal data will be discussed to elaborate on the potential therapeutic mechanisms of elevated KBs in migraine pathophysiology, with a particular focus on the actions of D-BHB. In complex diseases such as migraines, a therapy that can target multiple possible pathogenic pathways seems advantageous. Further research is needed to establish whether the absence/restriction of dietary carbohydrates, the presence of KBs, or both, are of primary importance for the migraine protective effects of the KD.
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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor So apr 20, 2019 20:50

Re: Keto/Low carb študije

Eno izmed nevroloških obolenj pri katerem kot terapija svoj potencial spet kaže ketogena dieta je tudi multipla skleroza (pravzaprav sedaj že pri večjem delu najbolj pogostih).
Ravno je objavljena še ena pozitivna raziskava na to temo.
Modified Ketogenic Diet Therapy for Relapsing Multiple Sclerosis: Patient-Reported Outcomes (P3.2-044)
Abstract
Objective: To report the multiple sclerosis (MS) patient experience after completion of a 6 month trial of a modified ketogenic diet.
Background: Dietary intake influences an individual’s immune profile and response. The impact of diet in MS is clinically meaningful, with evidence supporting an association between diet and disability. We have previously reported evidence of safety and adherence of ketogenic diets (KDs) in relapsing-remitting MS (RRMS) patients, with improvements in fatigue, depression, and disability metrics.
Design/Methods: Twenty patients with a diagnosis of RRMS were enrolled. Subjects were educated in-person by a trained dietitian on how to adhere to a modified KD (i.e. modified Atkins or KDMAD). Adherence to diet was objectively monitored by daily urine ketone testing. Clinical and patient-reported outcome measures were obtained at baseline (pre-diet) and after 6 months of treatment. A patient-experience survey was completed at the time of diet trial completion.
Results: Of the 20 subjects enrolled at baseline, two subjects were lost to follow-up. From the remaining 18 subjects, over half had previously attempted a diet for their MS. Upon completing the 6 month trial of KDMAD, 56% of subjects planned to continue on strict KDMAD after trial completion. All 18 subjects would recommend KDMAD to a colleague. The most common patient-perceived benefits of KDMAD included weight loss (83%), improved fatigue (72%), improved exercise habits (55.5%), improved stamina (50%), and reduced MS symptoms (45%). The most common side effects experienced on KDMAD included constipation (28%), menstrual irregularities (22%), and diarrhea (17%).
Conclusions: The KDMAD is a feasible diet for RRMS patients and provides multiple patient-perceived benefits that are clinically-relevant to MS subjects. As the majority of our subjects plan to continue on KDMAD, longitudinal clinical and laboratory data collection is ongoing.
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Grom

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Ne apr 21, 2019 17:18

Re: Keto/Low carb študije

Ketoni varujejo mišice

Med zanimivejšimi keto odkritji zadnjih let je antikataboličen in anaboličen učinek ketonov/keto diete. To velja predvsem za katabolne razmere, kot so regeneracija po poškodbah, operacijah ter opeklinah oziroma še bolj zanimiv je njihov antikatabolen vpliv pri sarkopeniji (izguba mišič s staranjem) in kaheksiji (izguba pustega tkiva pri rakavih bolnikih).

Kot kaže gre predvsem za protivnetno in antioksidativno delovanje ketonskih telesc. Prav tako pa imajo ketoni tudi anabolen učinek. Torej spodbujajo izgradnjo mišičnega tkiva.

Od avtorjev na zadnje objavljenega znanstvenega članka:

Experimentally, an elevation of plasma ketones reduced muscle protein turnover in catabolic scenarios, such as surgical recovery, skeletal trauma, sepsis, and severe burns [2]

Ketones have even been shown to promote muscle protein synthesis in humans and animal models [3, 4]

In a study of inflammation-induced muscle atrophy, the ketone body, BHB, reduced the marker of muscle breakdown used in this experiment (phenylalanine efflux from muscle) by 70%. They even compared the effects with hyperinsulinemia and BHB was a more potent anticatabolic stimulus [5]

Ketones may just be something that can shine in real-life situations such as sarcopenia, disuse, and disease-related atrophy, such as cancer cachexia. Therapeutic ketosis, whether induced with a ketogenic diet or exogenous ketones, is safe and tolerable. Not to mention that ketones offer a host of other benefits outside of their muscle sparing effects.

https://www.ncbi.nlm.nih.gov/pubmed/30712977
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Grom

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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor To apr 23, 2019 14:13

Re: Keto/Low carb študije

Mogoče zanimiva raziskava, ki potrjuje redke človeške in nekatere predhodne živalske študije ter tudi praktične izkušnje oziroma poročanje oseb o spremembah na ketogeni dieti. Ketogena dieta ima lahko močan vpliv na zmanjšanje anksioznosti, depresij in podobnih stanj.

Sicer gre tu za bolnike za epilepsijo, ki so seveda najbolj raziskovana skupina ljudi na ketogeni dieti (najbolj učnkovita metoda zdravljenja) vendar lahko te ugotovitev prenesemo tudi na drugo populacijo..

Psychiatric Effects of Ketogenic Diet Therapies on Adults with Chronic Epilepsy (P1.5-004)


Objective: To survey adults starting and currently on ketogenic diet therapy (KDT) for chronic epilepsy and determine whether there are beneficial effects on depression and anxiety.

Background: Ketogenic Diet Therapies are nonpharmacologic treatments shown to be effective in children and adults with intractable epilepsy. Little is known about the effects of KDT on mood for adults with epilepsy. An estimated 37% of people with epilepsy have psychiatric disturbances. Although KDTs require certain diet restrictions, a low carbohydrate, high fat diet may improve negative affect in patients with or without existing comorbid psychiatric disorders.

Design/Methods: For adults already on a KDT for 3 months or more, a retrospective survey was administered assessing their mood prior to and while on a KDT. Patients that were diet naïve completed a prospective pre-diet survey as well as one or more on-diet surveys after 3 months or more on-diet. KDT responders were defined as experiencing ≥ 50% seizure reduction.

Results: Of 33 adults on KDT that completed the retrospective survey, 91% reported symptoms of anxiety (28) and/or depression (29) prior to starting. Sixteen (48%) reported reduction in either anxiety (1), depressive symptoms (5), or both (10) on KDT. Thirty-three percent had anxiety and/or depressive symptoms worsen. Twenty-seven percent had all symptoms remain the same or solely anxiety symptoms remain the same. In 3 patients who completed prospective surveys, 66% showed dramatically improved anxiety and depressive symptoms and all participants responded to KDT. One participant without improvement reported increased anxiety.

Conclusions: Chronic psychiatric symptoms may be under-reported in adults with epilepsy. The majority of anxiety and depressive symptoms improved among nearly half of patients examined retrospectively and two thirds of patients examined prospectively. Patients with worsening symptoms were symptomatic at baseline, indicating KDT likely did not result in development of psychiatric symptoms. KDT may reduce psychiatric symptoms in adults with chronic epilepsy.
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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Sr maj 01, 2019 19:26

Re: Keto/Low carb študije

Potencialna varovalna vloga ketonov pri poškodbah možganov zaradi udarcev ( kontaktni športi, nesreče.. ) je bila že nekajkrat potrjena v raziskavah. Ketoni zmanjšujejo škodo in pospešujejo regeneracijo. Glavno naj bi bilo njihovo protivnetno in antiokisdativno delovanje.

Do tega učinka lahko seveda pridemo s ketogeno dieto, eksternimi ketoni ali pa blokiranjem prevzema glukoze.



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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Sr maj 08, 2019 17:58

Re: Keto/Low carb študije

Še ena raziskava pod vodstvom Halla, ki tistim ki zadeve ne poznajo poda napačne informacije in zavaja.. Objavljam jo preden bodo vrli prehranski svetovalci in časopisi ponovno napadli LCHF prehrano. Torej po 4 tednih keto prehrane je on ugotovil padec trigliceridov, inzulina in dvih LDLa ter CRPja, ki je vnetni marker. Vse je ok razen poudarek na dvigu vnetnega markerja CRP. Ta prehrana vnetna stanja zmanšuje in pri ljudeh, ki imajo kronično CRP visok ta pade in se umiri. Je poznana, kot protivnetna prehrana. Res pa je, da v prvih nekaj tednih ta pogosto rahlo poraste in potem pade. Zakaj ni še jasne razlage vendar tudi v naši raziskavi, ki smo jo izvedli v Izoli in ketere glavni dietetik sem bil se je to zgodilo. Hipoteza je, da gre za nenavajenost prebavnega trakta na toliko maščob v hrani ali pa kar sproščanje vnetnih omega 6 maščob iz zalog pri ljudeh, ki hitro hujšajo, ki so tam zaradi prejšne prehrane.. Torej zelo kratkoročno in na dolgi rok ravno obratno, kot bo sklepal nek prehranski strokovnjak ali novinar ko bo prebal tale povzetek ter spet povzročil paniko...

Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet

The objective of this study was to measure changes in glucose, lipid, and inflammation parameters after transitioning from a baseline diet (BD) to an isocaloric ketogenic diet (KD).
Methods

Glucose homeostasis, lipid homeostasis, and inflammation were studied in 17 men (BMI: 25‐35 kg/m2) during 4 weeks of a BD (15% protein, 50% carbohydrate, 35% fat) followed by 4 weeks of an isocaloric KD (15% protein, 5% carbohydrate, 80% fat). Postprandial responses were assessed following mixed‐meal tests matched to compositions of the BD (control meal [CM]) and KD (ketogenic meal).
Results

Fasting ketones, glycerol, free fatty acids, glucagon, adiponectin, gastric inhibitory peptide, total and low‐density lipoprotein cholesterol, and C‐reactive protein were significantly increased on the KD. Fasting insulin, C‐peptides, triglycerides, and fibroblast growth factor 21 were significantly decreased. During the KD, the glucose area under the curve was significantly higher with both test meals, and the insulin area under the curve was significantly higher only for the CM. Analyses of glucose homeostasis suggested that the KD insulin sensitivity decreased during the CM but increased during the ketogenic meal. Insulin‐mediated antilipolysis was decreased on the KD regardless of meal type.
Conclusions

Switching to the KD was associated with increased cholesterol and inflammatory markers, decreased triglycerides, and decreased insulin‐mediated antilipolysis. Glucose homeostasis parameters were diet dependent and test meal dependent.
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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor So maj 11, 2019 21:36

Re: Keto/Low carb študije

Še ena izmed razsikav za spreminjanje pogleda na prehrano tako pri naših najbližjih, kot raznih svetovalcih in tudi zdravnikih. Če imamo zamaščene organe in povišane trigliceride nam vsi svetujejo izločanje maščob iz prehrane. Raziskave in praksa pa kažejo ravno obratno. Ko se delež OH niža in delež maščob viša bomo pričeli učinkovito kuriti maščobe za energijo. Prvo, kar se bo zgodilo po padec trigliceridov v krvi in odmastitev organov oziroma izguba najbolj škodljive maščobe v telesu. Iz tega oziroma presnovnega sindroma sem pred leti delal diplomo in obstaja kup raziskav.
Ravno objavljena raziskava v tej smeri...



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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe maj 17, 2019 19:01

Re: Keto/Low carb študije

Objavjljena je še ena razikava, ki kaže varovalni učinek ketogene diete pri poškodbah možganov. Zadeva se na veliko raziskuje pri ameriških nogometaših in je seveda zanimiva pri vseh kontaktnih športih, kot tudi nesrečah na splošno.

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury
Jenny B. Koenig, David Cantu, Cho S. Low, Mary E. Sommer, Farzad Noubary, Danielle Croker, Michael Whalen, Dong Kong, and Chris G. Dulla


Abstract

Traumatic brain injury (TBI) causes cortical dysfunction and can lead to post-traumatic epilepsy. Multiple studies demonstrate that GABAergic inhibitory network function is compromised following TBI, which may contribute to hyperexcitability and motor, behavioral, and cognitive deficits. Preserving the function of GABAergic interneurons, therefore, is a rational therapeutic strategy to preserve cortical function after TBI and prevent long-term clinical complications. Here, we explored an approach based on the ketogenic diet, a neuroprotective and anticonvulsant dietary therapy which results in reduced glycolysis and increased ketosis. Utilizing a pharmacologic inhibitor of glycolysis (2-deoxyglucose, or 2-DG), we found that acute in vitro application of 2-DG decreased the excitability of excitatory neurons, but not inhibitory interneurons, in cortical slices from naïve mice. Employing the controlled cortical impact (CCI) model of TBI in mice, we found that in vitro 2-DG treatment rapidly attenuated epileptiform activity seen in acute cortical slices 3 to 5 weeks after TBI. One week of in vivo 2-DG treatment immediately after TBI prevented the development of epileptiform activity, restored excitatory and inhibitory synaptic activity, and attenuated the loss of parvalbumin-expressing inhibitory interneurons. In summary, 2-DG may have therapeutic potential to restore network function following TBI.
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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jun 28, 2019 20:56

Re: Keto/Low carb študije

Še najnovejša med sedaj že številnimi raziskavami o pozitivnem vplivu ketogene diete na delovanje možganov. Tokrat ponovno pozitivno delovanje pri starejših dementnih in Alzhemirejevih bolnikih.. Seveda lahko ob tem ponovno pomislimo na ketogeno prehrano, kot preventivo.. Celo več. Raziskave kažejo na močno antioksidativno in protivnetno delovanje, tvorjenje novih možganskih povezav itd.

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease

Abstract: Ketone bodies, the products of fat metabolism, are a source of energy for the brain and are available even when glucose supplies are inadequate (such as with severe carbohydrate deprivation) or its metabolism is faulty (as it is in Alzheimer’s disease). This phase I/II randomized clinical trial examined the feasibility of using a modified Atkins diet (MAD) to induce ketogenesis in persons with mild cognitive impairment (MCI) or early AD, and the effect of this diet on memory and other clinical outcomes. In the first 2.5 years of active recruitment, only 27 eligible and willing patients enrolled. After extensive assessment and education, they and their study partners were randomly assigned for 12 weeks to either the MAD or the National Institute on Aging (NIA) recommended diet for seniors. As of April 2018, 9 patients in the MAD arm and 5 in the NIA arm have completed the trial. In spite of extensive teaching, coaching, and monitoring, adherence to both diets was only fair. Among those in the MAD arm who generated at least trace amounts of urinary ketones, there was a large (effect size = 0.53) and statistically significant (p = 0.03) increase in Memory Composite Score between the baseline and week-6 assessment. MAD participants also reported increased energy between baseline and week-6 assessment. Despite challenges to implementing this trial, resulting in a small sample, our preliminary data suggest that the generation of even trace ketones might enhance episodic memory and patient-reported vitality in very early AD.
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Šefe

Vnosov: 63848

Pridružen: Če sep 23, 2004 18:35

Odgovor To jul 16, 2019 17:30

Re: Keto/Low carb študije

Gripa: kako pomaga ustrezna hrana

Gripa je zelo nalezljiva virusna bolezen, ki se hitro širi in povzroča epidemije in pandemije. Zaradi gripe je v preteklosti umrlo na milijone ljudi.

Na nedavnem srečanju Ameriške zveze imunologov je skupina znanstvenikov z medicinske fakultete na Univerzi Yale predstavila zanimiv eksperiment. Skupino mišk so prehranjevali po pravilih ketogene diete. Ugotovili so, da se jim, ko so enkrat prilagojene na keto prehrano, poveča število gama delta celic T v pljučih, ki so učinkovite kot protivirusna obramba. Še bolj zanimivo je njihovo opažanje, da so bile proti gripi bolje opremljene keto-adaptirane miške: samo infuzija eksternih ketonskih telesc ni imela enakega učinka (Goldberg in sod., 2019).


https://www.lchflove.si/2019/07/16/grip ... zna-hrana/

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Šefe

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Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jul 19, 2019 20:42

Re: Keto/Low carb študije

Še najnovejša znanstveni članek. Keto in diabetes tipa 1. Bolezen na tej prehrani v remisiji.

A low-carbohydrate high-fat diet initiated promptly after diagnosis provides clinical remission in three patients with type 1 diabetes.
Diabetes& Metabolism. j.diabet.2019.06.004
Bouillet, B., Rouland, A., Petit, J. M., & Vergès, B. (2019)
In conclusion, we report here, for the first time, the cases of three T1D patients who experienced clinical remission after commencing an LCHF diet soon after their diagnosis. Implementation of such a diet resulted in optimal glycaemic control while the frequency of hypoglycaemia was low, although the effect on lipid parameters was variable. In any case, the LCHF diet, if introduced promptly, could preserve b-cell function in patients with residual insulin secretion at diagnosis. Thus, an LCHF diet appears to be a feasible therapeutic option in self-motivated adults with T1D, provided that their lipid parameters are carefully controlled, and early introduction of the LCHF diet may well lead to clinical remission of T1D.
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