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Danes je To avg 20, 2019 22:08

Keto/Low carb študije

Moderatorji: UrosS, Metka, Stasa, Grom

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Grom

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Šefe

Vnosov: 63803

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe jul 19, 2019 20:43

Re: Keto/Low carb študije

Limfa, limfne žleze, limfedem in keto / LCHF

Eno od novejših odkritij je razkrilo, da je za regulacijo in rast limfnih žil esencialnega pomena acetil koencim A, ena od spojin, ki nastaja med presnovo. Preprosto povedano, acetil koencim A lahko sproži rast limfnih žil in izboljša njihovo delovanje tudi v bolezenskih razmerah, kot je na primer limfedem. Ker acetil koencim A lahko nastaja iz ketonov
, se je znanstvenikom porodila ideja, da bi nemara dodajanje ketonov povečalo razpoložljivo količino acetil koencima A in ugodno vplivalo na limfatični sistem.

To zanimivo idejo so sprva preskusili na človeških celicah v epruveti, potem pa še na živih miškah, ki so jim predpisali ketogeno dieto – in pri obeh se je izkazalo, da deluje.




https://www.lchflove.si/

2019/07/15/

limfa-limfne-zleze-limfedem

-in-keto-lchf/






Slika
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Grom

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Šefe

Vnosov: 63803

Pridružen: Če sep 23, 2004 18:35

Odgovor To jul 30, 2019 09:41

Re: Keto/Low carb študije

12 tednov ketogene diete je ne samo stabilziralo diabetes tipa 2, temveč je stanje reverzibiralo. Glikiran hemoglobin se je po 26 letih po diagnozi diabetesa vrnil v normalne vrednosti! Da ne govorimo o pozitivnem pogledu na življenje in odpravi depresije!

In potem še vedno vidim članek, da to ni prava prehrana za diabetike :)

Ketogenic diets potentially reverse Type II diabetes and ameliorate clinical depression: A case study.
Cox N1, Gibas S1, Salisbury M1, Gomer J2, Gibas K3.
Author information
Abstract

Efficacious adherence to treatment protocol predicts metabolic control among Type 2 diabetics (T2DM) [1-4]; however, few healthcare systems employ individualized strategies to mediate the comorbidity of T2DM with other chronic disease states. A clinically prescribed ketogenic diet, patient-centered nutritional education and high intensity interval training (HIIT), girded by solution-focused psychotherapy, modulate significant improvements in the clinical biomarkers associated with concurring T2DM and clinical depression [5-15]. Relevant metabolic change was noted in the following measures: HOMA-IR, triglyceride/HDL ratio, HgA1c, fasting insulin, fasting glucose, fasting triglycerides, LDL, VLDL, HDL, total cholesterol and C-reactive protein. The Patient Health Questionnaire 9 (PHQ-9) along with clinical interview and the mental status exam showed notable change in the patient's depressive symptoms; likewise, her self-efficacy score normalized, as measured by the General Self-Efficacy Questionnaire (GSE) and the Metabolic Syndrome Compliance Questionnaire (MSC). The case study highlights a 65-year old female who presented with a 26-year history of dually-diagnosed Type 2 diabetes (T2DM) and major depressive disorder (MDD). The patient was prescribed a ketogenic diet (KD), clinically formulated from her resting metabolic rate, body fat percentage and lean body mass, together with weekly nutrition education, high intensity interval training (matched to her cardiovascular conditioning), and eight 45-minute solution-focused psychotherapy sessions. Intervention goals included improved insulin sensitivity evaluated by the HOMA-IR, sustained glycemic control measured via HgA1c, reduced cardiovascular risk via the triglyceride/HDL ratio, and improved depressive symptoms with increased self-efficacy monitored by the PHQ-9 and GSE/MSC. The results of the 12-week intervention were statistically significant. The patient's HgA1c dropped out of diabetic range (8.0%) and normalized at 5.4%. Her average daily glucose measurements declined from 216 mg/dL to 96 mg/dL; the HOMA-IR and triglyceride/HDL ratios improved by 75%. Her marker for clinical depression and measurement of self-efficacy normalized. The 12-week individualized treatment intervention served to functionally reverse 26 years of T2DM, ameliorate two and half decades of chronic depressive disorder and empower/equip the patient with a new experience of hope and success.
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Grom

Uporabniški avatar

Šefe

Vnosov: 63803

Pridružen: Če sep 23, 2004 18:35

Odgovor Pe avg 02, 2019 08:12

Re: Keto/Low carb študije

Več raziskav kaže na pozitiven vpliv ketogene diete pri zmanjševanju pojava kroničnih glavobolov. To seveda vidimo tudi v praksi. Toda, kot kažejo moje izkušnje za optimum ni pomembna le LCHF prehrana temveč stanje visoke ketoze. Torej stroga ketogena dieta. Podobno v raziskavi:

Nutrients. 2019 Jul 28;11(8). pii: E1742. doi: 10.3390/nu11081742.
A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?


Here we aimed at determining the therapeutic effect of a very low-calorie diet in overweight episodic migraine patients during a weight-loss intervention in which subjects alternated randomly between a very low-calorie ketogenic diet (VLCKD) and a very low-calorie non-ketogenic diet (VLCnKD) each for one month. In a nutritional program, 35 overweight obese migraine sufferers were allocated blindly to 1-month successive VLCKD or VLCnKD in random order (VLCKD-VLCnKD or VLCnKD-VLCD). The primary outcome measure was the reduction of migraine days each month compared to a 1-month pre-diet baseline. Secondary outcome measures were 50% responder rate for migraine days, reduction of monthly migraine attacks, abortive drug intake and body mass index (BMI) change. Only data from the intention-to-treat cohort (n = 35) will be presented. Patients who dropped out (n = 6) were considered as treatment failures. Regarding the primary outcome, during the VLCKD patients experienced -3.73 (95% CI: -5.31, -2.15) migraine days respect to VLCnKD (p < 0.0001). The 50% responder rate for migraine days was 74.28% (26/35 patients) during the VLCKD period, but only 8.57% (3/35 patients) during VLCnKD. Migraine attacks decreased by -3.02 (95% CI: -4.15, -1.88) during VLCKD respect to VLCnKD (p < 0.00001). There were no differences in the change of acute anti-migraine drug consumption (p = 0.112) and BMI (p = 0.354) between the 2 diets. A VLCKD has a preventive effect in overweight episodic migraine patients that appears within 1 month, suggesting that ketogenesis may be a useful therapeutic strategy for migraines.
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